![]() ![]() If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is a potential cross-sensitivity between silver sulfadiazine and other sulfonamides. ![]() Some of the reactions which have been associated with sulfonamides are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions, hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Results of in Vitro Testing With Silver Sulfadiazine Cream, USP 1% Concentration of Silver Sulfadiazine Number of Sensitive Strains / Total Number of Strains Tested Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. Results from in vitro testing are listed below. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Your health care provider will tell you what to do if you have side effects.Silver sulfadiazine has broad antimicrobial activity. Ask your health care provider if there are interactions between sulfadiazine and the other medicines you take.Īsk your health care provider about possible side effects from sulfadiazine. Sulfadiazine may affect the way other medicines or products work, and other medicines or products may affect how sulfadiazine works. About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take.People with suppressed viral load have a less than 1% chance of transmitting HIV to their baby via their own milk. For people with HIV in the United States, the Guideline recommends speaking with your health care provider to discuss options for feeding your baby. If you are breast/chestfeeding or plan to breast/chestfeed.Please refer to these guidelines for additional information. The Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV may include other recommendations on the use of sulfadiazine during pregnancy. Talk to your health care provider about the risks and benefits of taking sulfadiazine during pregnancy. If you are pregnant or plan to become pregnant.About anything that could affect your ability to take medicines, such as difficulty swallowing or remembering to take pills.blood disorders, including glucose-6-phosphate dehydrogenase (G-6PD) deficiency. ![]() About any medical conditions you have or have had, including the following:.If you are allergic to sulfadiazine, sulfonamides ( sulfa medicines), or any other medicines. ![]() What should I tell my health care provider before taking sulfadiazine? What should I tell my health care provider before taking sulfadiazine? What should I tell my health care provider before taking sulfadiazine?īefore taking sulfadiazine, tell your health care provider: ![]()
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